| Identification | Back Directory | [Name]
Fendiline | [CAS]
13042-18-7 | [Synonyms]
N-(1-Phenylethyl)-3,3-diphenylpropylamine
3,3-diphenyl-N-(1-phenylethyl)propan-1-amine | [EINECS(EC#)]
235-915-6 | [Molecular Formula]
C23H25N | [MOL File]
13042-18-7.mol | [Molecular Weight]
315.45 |
| Hazard Information | Back Directory | [Originator]
Sensit,Thiemann,W. Germany,1974 | [Definition]
ChEBI: 3,3-diphenyl-N-(1-phenylethyl)-1-propanamine is a diarylmethane. | [Manufacturing Process]
21.13 grams of γ,γ-diphenyl-propylamine and 12.01 grams of acetophenone
are hydrogenated in 200 ml of methanol at 55°C and a pressure of 10
atmospheres in the presence of palladium charcoal. On filtration of the
catalyst the solution is concentrated and the remainder is distilled in vacuo at
a pressure of 0.3 Hg mm. The main distillate is collected at 206° to 210°C.
25.38 grams of N-[1'-phenylethyl-(1')]-1,1-diphenyl-propyl-(3)-amine are
obtained.
The product is dissolved in 134 ml of 96% ethanol whereupon 26.8 ml of
concentrated hydrochloric acid and 201 ml of water are added while cooling
with ice-water. The precipitate is filtered off and dried in vacuo at 100°C.
22.98 grams of N-[1'-phenylethyl)-(1')]-1,1-diphenyl-propyl-(3)-amine
hydrochloride are obtained. MP 200° to 201°C. On recrystallization from 285
ml of a 2:1 mixture of water and 96% ethanol the melting point remains
unchanged. | [Therapeutic Function]
Coronary vasodilator |
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