| Identification | Back Directory | [Name]
Peucedanocoumarin III | [CAS]
130464-57-2 | [Synonyms]
Peucedanocoumarin III
(2E)-2-Methyl-2-butenoic acid (9S,10R)-9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-10-yl ester | [Molecular Formula]
C21H22O7 | [MOL File]
130464-57-2.mol | [Molecular Weight]
386.4 |
| Chemical Properties | Back Directory | [Boiling point ]
486.8±45.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder |
| Hazard Information | Back Directory | [Description]
Peucedanocoumarin Ⅲ can induce rice resistance to blast disease. | [Uses]
Peucedanocoumarin III is an inhibitor of (alpha)-synuclein and Huntington protein aggregates that enhances the clearance of nuclear and cytoplasmic β23 aggregates and prevents cytotoxicity induced by disease-associated proteins (i.e., mutant Huntington proteins and α-synuclein). Peucedanocoumarin III may be used in Parkinson's disease research[1]. | [IC 50]
α-synuclein Aggregation | [References]
[1] Sangwoo Ham, et al. Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates. Mol Cells. 2019 Jun 30;42(6):480-494. DOI:10.14348/molcells.2019.0091 |
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