| Identification | Back Directory | [Name]
2,2-DIMETHYL-MALONIC ACID MONOMETHYL ESTER | [CAS]
13051-21-3 | [Synonyms]
2,2-DIMETHYL-MALONIC ACID MONOMETHYL ESTER
3-Methoxy-2,2-diMethyl-3-oxopropanoic acid
Propanedioic acid, 2,2-dimethyl-, 1-methyl ester | [Molecular Formula]
C6H10O4 | [MDL Number]
MFCD09833517 | [MOL File]
13051-21-3.mol | [Molecular Weight]
146.14 |
| Chemical Properties | Back Directory | [Melting point ]
35-38 °C | [Boiling point ]
78.5 °C(Press: 20 Torr) | [density ]
1.0624 g/cm3 | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
2.92±0.36(Predicted) | [Appearance]
Colorless to off-white <35°C Solid,>38°C Liquid |
| Hazard Information | Back Directory | [Synthesis]
To a round-bottomed flask containing a solution of THF:MeOH (50 mL, 1:5, v/v) with KOH (46.46 mmol) was slowly added 2,2,5,5-tetramethyl-1,3-dioxane-4,6-dione (11.61 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 24 hours. After completion of the reaction, the mixture was poured into a solution of 1 M HCl (50 mL) and extracted with ether. The organic phases were combined, washed with saturated brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give monomethyl 2,2-dimethylmalonate in 88% yield. | [References]
[1] European Journal of Medicinal Chemistry, 2013, vol. 64, p. 169 - 178 |
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