| Identification | Back Directory | [Name]
perimetazine | [CAS]
13093-88-4 | [Synonyms]
AN 1317
AN-1317
Leptryl
RP 9159
RP-9159
perimetazine
1-[3-(2-methoxyphenothiazin-10-yl)-2-methylpropyl]piperidin-4-ol
1-(3-(2-Methoxy-10H-phenothiazin-10-yl)-2-methylpropyl)piperidin-4-ol | [EINECS(EC#)]
236-009-3 | [Molecular Formula]
C22H28N2O2S | [MDL Number]
MFCD00867994 | [MOL File]
13093-88-4.mol | [Molecular Weight]
384.541 |
| Hazard Information | Back Directory | [Originator]
Leptryl ,Roger Bellon, France,1970 | [Uses]
Perimethazine, is a novel Antipsychotic drug. It has shown to cause sedation, hypothermia, muscle relaxation, and other signs of central depression in rabbits. | [Definition]
ChEBI: Perimetazine is a member of phenothiazines. | [Manufacturing Process]
A solution of 3-methoxy-10-(3-chloro-2-methylpropyl)phenthiazine (9.65 grams) and 4-hydroxypiperidine (6.1 grams) in xylene (10 cc) is heated under reflux for 5 hours. After cooling the mixture is diluted with ether (60 cc) and the basic compounds are extracted by agitation with water (30 cc) and 4 N hydrochloric acid (20 cc). The aqueous acid phase is made alkaline with 4 N sodium hydroxide solution (23 cc) and the liberated base is extracted with ether. The ethereal solution is washed with water (60 cc) and dried over sodium sulfate. Finally the solvent is distilled off on a water-bath.
The solid residue obtained is recrystallized from a mixture (15:85) of benzene and cyclohexane and there is obtained 3-rnethoxy-10-[2-methyl-3-(4hydroxy-1-piperidyl)-propyl]-phenthiazine (5.7 grams) as a white crystalline powder, MP 137°-138°C. | [Therapeutic Function]
Tranquilizer |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|