| Identification | Back Directory | [Name]
RO8994 | [CAS]
1309684-94-3 | [Synonyms]
RO8994
CS-2264
RO-8994;RO 8994
RO8994;RO-8994;RO 8994
(2'S,3R,4'S,5'R)-N-[4-(Aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide
Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)- | [Molecular Formula]
C31H31Cl2FN4O4 | [MDL Number]
MFCD29472243 | [MOL File]
1309684-94-3.mol | [Molecular Weight]
613.51 |
| Chemical Properties | Back Directory | [Boiling point ]
753.5±60.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF:12.5(Max Conc. mg/mL);20.4(Max Conc. mM)
DMSO:14.0(Max Conc. mg/mL);22.8(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);8.1(Max Conc. mM) | [form ]
A crystalline solid | [pka]
12.00±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
MURAVORBGFDSMA-ISKXDESKSA-N | [SMILES]
N1C2=C(C=CC(Cl)=C2)[C@@]2([C@@H](C3=CC=CC(Cl)=C3F)[C@H](C(NC3=CC=C(C(N)=O)C=C3OC)=O)N[C@H]2CC(C)(C)C)C1=O |
| Hazard Information | Back Directory | [Description]
RO8994 is an inhibitor of the protein-protein interaction between MDM2 and the tumor suppressor p53 in a homogeneous time-resolved fluorescence (HTRF) binding assay (IC50 = 5 nM).1 It inhibits the proliferation of SJSA-1, RKO, and HCT116 cells with an average IC50 value of 20 nM and increases apoptosis in SJSA-1 cells in a concentration-dependent manner. RO8994 reduces tumor growth and induces tumor regression in an SJSA-1 osteosarcoma mouse xenograft model when administered at doses of 1.56 and 6.25 mg/kg, respectively. | [Uses]
RO 8994 is a potent and selective spiroindolinone MDM2 inhibitor, and potential useful for cancer therapy. | [References]
[1] ZHUMING ZHANG . Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy[J]. Bioorganic & Medicinal Chemistry, 2014, 22 15: Pages 4001-4009. DOI: 10.1016/j.bmc.2014.05.072 |
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| Company Name: |
D&C Chemicals
|
| Telephone: |
+86-21-58447131 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
| Company Name: |
Twochem Co.Ltd
|
| Telephone: |
021-021-58111628 15800915896 |
| Website: |
www.twochem.com |
|