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1310012-12-4

1310012-12-4 Structure

1310012-12-4 Structure
IdentificationBack Directory
[Name]

3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-
[CAS]

1310012-12-4
[Synonyms]

3-Pyridinecarboxamide, N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-
[Molecular Formula]

C18H15FN2O
[MOL File]

1310012-12-4.mol
[Molecular Weight]

294.32
Chemical PropertiesBack Directory
[Boiling point ]

506.8±45.0 °C(Predicted)
[density ]

1.27±0.1 g/cm3(Predicted)
[storage temp. ]

4°C, protect from light
[solubility ]

DMSO : 83.33 mg/mL (283.13 mM; Need ultrasonic)
[form ]

Solid
[pka]

13.78±0.20(Predicted)
[color ]

Light yellow to brown
Hazard InformationBack Directory
[Uses]

VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1]. VU0360172 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
[Biological Activity]

VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].
[IC 50]

mGluR5: 16 nM (EC50); mGluR5: 195 nM (Ki)
[References]

[1]. Zuena AR, et al. In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator. Front Pharmacol. 2018 Jul 31;9:804.
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