| Identification | Back Directory | [Name]
BWMISRWJRUSYEX-YOVIYTQZSA-N | [CAS]
1310012-15-7 | [Synonyms]
BWMISRWJRUSYEX-YOVIYTQZSA-N
Terbinafine-d3HCl (N-methyl-d3) | [Molecular Formula]
C21H26ClN | [MDL Number]
MFCD19705110 | [MOL File]
1310012-15-7.mol | [Molecular Weight]
327.9 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 14 mg/ml,DMSO: 10 mg/ml,Ethanol: 30 mg/ml | [form ]
A solid | [color ]
White to off-white | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Description]
Terbinafine-d3 is intended for use as an internal standard for the quantification of terbinafine by GC- or LC-MS. Terbinafine is a broad-spectrum antifungal agent that has activity against T. rubrum, T. mentagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 μg/ml). It selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 μM, respectively). Terbinafine (90-120 μM) induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and human umbilical vein endothelial cells (HUVECs). Formulations containing terbinafine have been used in the treatment of nail and skin fungal infections. | [Uses]
Terbinafine-d3 HCl (N-methyl-d3) (CAS# 1310012-15-7) is a useful isotopically labeled research compound. | [References]
[1] G PETRANYI H M J G Meingassner. Antifungal activity of the allylamine derivative terbinafine in vitro.[J]. Antimicrobial Agents and Chemotherapy, 1987, 31 9: 1365-1368. DOI: 10.1128/aac.31.9.1365
[2] N S RYDER M C D. Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes.[J]. Biochemical Journal, 1985, 230 3: 765-770. DOI: 10.1042/bj2300765
[3] WEN-SEN LEE. In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest[J]. International Journal of Cancer, 2003, 106 1: 125-137. DOI: 10.1002/ijc.11194
[4] PEI-YIN HO. Inhibition of human vascular endothelial cells proliferation by terbinafine[J]. International Journal of Cancer, 2004, 111 1: 51-59. DOI: 10.1002/ijc.20039 |
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