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1311136-84-1

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1311136-84-1 Structure

1311136-84-1 Structure
IdentificationBack Directory
[Name]

N/aa
[CAS]

1311136-84-1
[Synonyms]

(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione
2,4-Imidazolidinedione, 5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-, (5R)-
[Molecular Formula]

C18H19N3O4
[MDL Number]

MFCD32062776
[MOL File]

1311136-84-1.mol
[Molecular Weight]

341.36
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.59(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);87.88(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);14.65(Max Conc. mM)
[form ]

A crystalline solid
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

AUT1 is a positive modulator of the voltage-gated potassium channel subtypes Kv3.1b, Kv3.2a, and Kv3.3 (EC50s = 4.7, 4.9, and 31.6 μM, respectively, in a patch-clamp assay). It is selective for Kv3.1b, Kv3.2a, and Kv3.3 over Kv1.5 and Kv7.1/minK channels but also inhibits the serotonin (5-HT) transporter, 5-HT3 receptor, and α1 subunit-containing nicotinic acetylcholine receptor (nAChR) in a panel of 26 ion channels, receptors, and transporters. AUT1 increases tetraethylammonium-induced decreases in the firing frequency and amplitude of action potentials in mouse somatosensory cortex slices when used at concentrations of 1 and 10 μM.
[Uses]

(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione, is a novel modulator of Kv3 potassium channels which biological studies have shown it regulates the firing of parvalbumin-positive cortical interneurons.
[References]

[1] MARCELO D ROSATO-SIRI. A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons.[J]. Journal of Pharmacology and Experimental Therapeutics, 2015, 354 3: 251-260. DOI: 10.1124/jpet.115.225748
Spectrum DetailBack Directory
[Spectrum Detail]

N/aa(1311136-84-1)1HNMR
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