Identification | Back Directory | [Name]
Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(benzo[b]thien-2-ylmethyl)amino]-1-hydroxy- | [CAS]
1312345-89-3 | [Synonyms]
GSK5750 GSK-5750 GSK 5750 Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(benzo[b]thien-2-ylmethyl)amino]-1-hydroxy- | [Molecular Formula]
C16H12N4O2S | [MOL File]
1312345-89-3.mol | [Molecular Weight]
324.36 |
Hazard Information | Back Directory | [Description]
GSK5750 is an inhibitor of the ribonuclease H activity of HIV-1 reverse transcriptase. | [Uses]
GSK5750 is a specific and potent HIV-1 reverse transcriptase ribonuclease H inhibitor with an IC50 value of 0.33 μM. GSK5750 is bound at the RNase H active site through a metalion chelation mechanism[1]. | [References]
[1] Beilhartz GL, et al. Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation. J Biol Chem. 2014 Jun 6;289(23):16270-7. DOI:10.1074/jbc.M114.569707 |
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