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1312345-89-3

1312345-89-3 Structure

1312345-89-3 Structure
IdentificationBack Directory
[Name]

Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(benzo[b]thien-2-ylmethyl)amino]-1-hydroxy-
[CAS]

1312345-89-3
[Synonyms]

GSK5750
GSK-5750
GSK 5750
Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(benzo[b]thien-2-ylmethyl)amino]-1-hydroxy-
[Molecular Formula]

C16H12N4O2S
[MOL File]

1312345-89-3.mol
[Molecular Weight]

324.36
Chemical PropertiesBack Directory
[Boiling point ]

604.8±65.0 °C(Predicted)
[density ]

1.54±0.1 g/cm3(Predicted)
[pka]

7.51±0.40(Predicted)
Hazard InformationBack Directory
[Description]

GSK5750 is an inhibitor of the ribonuclease H activity of HIV-1 reverse transcriptase.
[Uses]

GSK5750 is a specific and potent HIV-1 reverse transcriptase ribonuclease H inhibitor with an IC50 value of 0.33 μM. GSK5750 is bound at the RNase H active site through a metalion chelation mechanism[1].
[References]

[1] Beilhartz GL, et al. Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation. J Biol Chem. 2014 Jun 6;289(23):16270-7. DOI:10.1074/jbc.M114.569707
1312345-89-3 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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