| Identification | Back Directory | [Name]
21H-Biline-8,12-dipropanoic acid, 3,18-diethyl-1,2,3,4,5,15,16,17,18,19,22,24-dodecahydro-2,7,13,17-tetramethyl-1,19-dioxo-, monohydrochloride, (2R,3R,4S,16S,17R,18R)- | [CAS]
13129-80-1 | [Synonyms]
21H-Biline-8,12-dipropanoic acid, 3,18-diethyl-1,2,3,4,5,15,16,17,18,19,22,24-dodecahydro-2,7,13,17-tetramethyl-1,19-dioxo-, monohydrochloride, (2R,3R,4S,16S,17R,18R)- | [Molecular Formula]
C33H46N4O6.ClH | [MOL File]
13129-80-1.mol | [Molecular Weight]
631.2 |
| Hazard Information | Back Directory | [Uses]
Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a Ki of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections[1][2]. | [References]
[1] Sanada S, et al. Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob mice. Sci Rep. 2020 Apr 15;10(1):6479. DOI:10.1038/s41598-020-63627-y
[2] McPhee F, Caldera PS, Bemis GW, McDonagh AF, Kuntz ID, Craik CS. Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro. Biochem J. 1996 Dec 1;320 ( Pt 2)(Pt 2):681-6. DOI:10.1042/bj3200681 |
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