| Identification | Back Directory | [Name]
LSN2814617 | [CAS]
1313498-08-6 | [Synonyms]
LSN2814617
LSN2814617 racemate
1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethy
3-(1,1-Dimethylethyl)-7-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridine
1,2,4-Triazolo[4,3-a]pyridine, 3-(1,1-dimethylethyl)-7-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-5,6,7,8-tetrahydro- | [Molecular Formula]
C18H20FN5O | [MOL File]
1313498-08-6.mol | [Molecular Weight]
341.38 |
| Hazard Information | Back Directory | [Uses]
(Rac)-LSN2814617 is a racemate of LSN2814617 (HY-118256)[1]. | [Biological Activity]
LSN2814617 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5).1 It potentiates glutamate-induced calcium mobilization in MCB3901 cells expressing human mGluR5 (EC50 = 52 nM). LSN2814617 increases rat hippocampal mGluR5 receptor occupancy (ED50 = 13 mg/kg). It increases wakefulness and decreases non-rapid eye movement (NREM) and REM sleep in rats when administered at doses of 0.3, 1, and 3 mg/kg. | [References]
1.Gilmour, G., Broad, L.M., Wafford, K.A., et al.In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the ratNeuropharmacology64224-239(2013)
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