| Identification | Back Directory | [Name]
Hemopressin (human, bovine, porcine) | [CAS]
1314035-51-2 | [Synonyms]
Hemopressin (human, bovine, porcine)
H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH | [Molecular Formula]
C50H79N13O12 | [MDL Number]
MFCD11975008 | [MOL File]
1314035-51-2.mol | [Molecular Weight]
1054.24 |
| Chemical Properties | Back Directory | [Boiling point ]
1491.3±65.0 °C(Predicted) | [density ]
1.258±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Powder | [pka]
2.77±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH |
| Hazard Information | Back Directory | [Uses]
Hemopressin is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin exerts antinociceptive action in inflammatory pain models[1][2]. | [in vivo]
Hemopressin causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE)[1].
Oral administration of Hemopressin inhibits mechanical hyperalgesia of CCI-rats up to 6h. Hemopressin treatment also decreases Egr-1 immunoreactivity (Egr-1Ir) in the superficial layer of the dorsal horn of the spinal cord of CCI rats[2].
| [storage]
Store at -20°C | [References]
[1] Garron T Dodd, et al. The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice. J Neurosci. 2010 May 26;30(21):7369-76. DOI:10.1523/JNEUROSCI.5455-09.2010
[2] Elaine F Toniolo, et al. Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats. Peptides. 2014 Jun;56:125-31. DOI:10.1016/j.peptides.2014.03.016 |
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