| Identification | Back Directory | [Name]
UNC 669 | [CAS]
1314241-44-5 | [Synonyms]
UNC699
CS-1146
UNC 669
UNC669, >=98%
UNC 669; UNC-669
UNC 669 USP/EP/BP
(5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone
(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone
METHANONE, (5-BROMO-3-PYRIDINYL)[4-(1-PYRROLIDINYL)-1-PIPERIDINYL]-
(5-Bromo-3-pyridinyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone UNC669 | [Molecular Formula]
C15H20BrN3O | [MDL Number]
MFCD26936345 | [MOL File]
1314241-44-5.mol | [Molecular Weight]
338.243 |
| Chemical Properties | Back Directory | [Boiling point ]
458.0±45.0 °C(Predicted) | [density ]
1.424±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20° C | [solubility ]
insoluble in H2O; ≥52.4 mg/mL in EtOH with ultrasonic; ≥9.35 mg/mL in DMSO | [form ]
solid | [pka]
9.78±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a selective inhibitor of malignant brain tumor (MBT). | [Definition]
ChEBI: (5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is an aromatic carboxylic acid and a pyridinemonocarboxylic acid. | [Biological Activity]
unc 669 is a potent antagonist of l3mbtl1 (ic50=4.2 μm) and l3mbtl3 (ic50=3.1 μm).there is less bio-data supported for unc669. unc1679 is an analog of unc669. unc1215 is the first potent and selective antagonism of a methyl-lysine reader protein, l3mbtl3, which antagonizes the mono- and dimethyl-lysine reading function of l3mbtl3. [1]lysine methylation is a key epigenetic landmark, the dysregulation of which is related to many diseases. unc1679 maintains in vitro and cellular potency with improved selectivity against other mbt-containing proteins. the antagonists described were also found to effectively interact with unlabeled endogenous l3mbtl3 in cells. [1] | [target]
L3MBTL1 | [References]
1. james li, korboukh vk, krichevsky l et al. small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for l3mbtl3. j med chem. 2013 sep 26;56(18):7358-71. doi: 10.1021/jm400919p. epub 2013 sep 16. |
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