| Identification | Back Directory | [Name]
Mal-amido-PEG5-C2-NHS ester | [CAS]
1315355-92-0 | [Synonyms]
Mal-amido-PEG5-C2-?NHS ester
4,7,10,13,16-Pentaoxa-19-azadocosanoic acid, 22-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-20-oxo-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C24H35N3O12 | [MDL Number]
MFCD20230002 | [MOL File]
1315355-92-0.mol | [Molecular Weight]
557.55 |
| Chemical Properties | Back Directory | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Storage temp. -20°C | [form ]
Viscous Liquid | [pka]
15.01±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Mal-amido-PEG10-C2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules[1][2] | [IC 50]
Non-cleavable Linker | [References]
[1] Hansen AM, et al. Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae. Eur J Med Chem. 2019 Apr 15;168:134-145. DOI:10.1016/j.ejmech.2019.02.024
[2] Zhang ge, et al. Preparation and application of FAPalpha activated polypeptide magnetic nanosphere compound used for diagnosis of tumors. CN105524141A |
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