| Identification | Back Directory | [Name]
5H-Pyrrolo[3,4-b]pyridin-5-one, 2-(5,6-dimethoxy-3-pyridinyl)-6,7-dihydro-7-methyl-6-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-, (7R)- | [CAS]
1315538-79-4 | [Synonyms]
PI-3Kγ inhibitor 2,PI3Kγ inhibitor 2
5H-Pyrrolo[3,4-b]pyridin-5-one, 2-(5,6-dimethoxy-3-pyridinyl)-6,7-dihydro-7-methyl-6-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-, (7R)- | [Molecular Formula]
C20H18F3N5O3 | [MDL Number]
MFCD31813664 | [MOL File]
1315538-79-4.mol | [Molecular Weight]
433.38 |
| Hazard Information | Back Directory | [Uses]
PI3Kγ inhibitor 2 (Compound 16) is an orally bioavailable, CNS-penetrant, isoform selective PI3Kγ inhibitor with a Ki of 4 nM[1]. | [IC 50]
PI3Kγ: 4 nM (Ki) | [References]
[1] Come JH, et al. Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS). J Med Chem. 2018 Jun 28;61(12):5245 DOI:10.1021/acs.jmedchem.8b00085 |
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