| Identification | Back Directory | [Name]
2,4-DICHLORO-5-AMINO-6-METHYLPYRIMIDINE | [CAS]
13162-27-1 | [Synonyms]
4-Dichloro-5-aMino-6-MethylpyriMidine
2,4-dichloro-6-methylpyrimidin-5-amine
2,4-Dichloro-6-methyl-5-pyrimidinamine
5-Amino-6-methyl-2,4-dichloropyrimidine
5-Pyrimidinamine,2,4-dichloro-6-methyl-
2,4-DICHLORO-5-AMINO-6-METHYLPYRIMIDINE
2,4-DICHLORO-6-METHYL-PYRIMIDIN-5-YLAMINE
Pyrimidine, 5-amino-2,4-dichloro-6-methyl-
2,4-DICHLORO-5-AMINO-6-METHYLPYRIMIDINE ISO 9001：2015 REACH
2,4-Dichloro-6-methylpyrimidin-5-amine, 5-Amino-2,4-dichloro-6-methyl-1,3-diazine | [Molecular Formula]
C5H5Cl2N3 | [MDL Number]
MFCD08062586 | [MOL File]
13162-27-1.mol | [Molecular Weight]
178.02 |
| Chemical Properties | Back Directory | [Melting point ]
115-116.5℃ | [Boiling point ]
281.6±35.0 °C(Predicted) | [density ]
1.504±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
-0.83±0.39(Predicted) | [Appearance]
Light brown to brown Solid | [InChI]
InChI=1S/C5H5Cl2N3/c1-2-3(8)4(6)10-5(7)9-2/h8H2,1H3 | [InChIKey]
FDMMHWIFYCXEOF-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC(C)=C(N)C(Cl)=N1 |
| Hazard Information | Back Directory | [Uses]
2,4-dichloro-6-methylpyrimidin-5-amine is an amine compound that can be used as a pharmaceutical intermediate or raw material for organic synthesis. | [Synthesis]
2,4-Dichloro-5-nitro-6-methylpyrimidine (860 mg) was used as a feedstock and co-dissolved with Pd/C (180 mg) in ethyl acetate (30 mL). Hydrogen was passed three times at room temperature to displace the air in the reaction system, followed by the reaction at 40 psi hydrogen pressure. Upon completion of the reaction, the Pd/C catalyst was removed by filtration to afford the yellow solid product 2,4-dichloro-5-amino-6-methylpyrimidine (500 mg) in 65.1% yield. | [References]
[1] Heterocyclic Communications, 2014, vol. 20, # 5, p. 275 - 279
[2] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0032
[3] Journal of Heterocyclic Chemistry, 2016, vol. 53, # 3, p. 832 - 839
[4] Journal of the American Chemical Society, 1954, vol. 76, p. 1953
[5] Yakugaku Zasshi, 1942, vol. 62, p. 315,333; dtsch. Ref. S. 95, 106 |
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