| Identification | Back Directory | [Name]
R-Pralatrexate | [CAS]
1320211-70-8 | [Synonyms]
R-Pralatrexate
Pralatrexate, (R)-
L-Glutamic acid, N-[4-[(1R)-1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]- | [Molecular Formula]
C23H23N7O5 | [MOL File]
1320211-70-8.mol | [Molecular Weight]
477.47 |
| Hazard Information | Back Directory | [Uses]
(R)-Pralatrexate is the (R)-enantiomer of Pralatrexate (HY-10446). Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor[1]. | [References]
[1] Enrica Marchi, et al. Pralatrexate Is Synergistic With the Proteasome Inhibitor Bortezomib in in Vitro and in Vivo Models of T-cell Lymphoid Malignancies. Clin Cancer Res. 2010 Jul 15;16(14):3648-58. DOI:10.1158/1078-0432.CCR-10-0671 |
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https://www.bocsci.com |
| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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