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1321361-13-0

1321361-13-0 Structure

1321361-13-0 Structure
IdentificationBack Directory
[Name]

3-Pyrrolidinamine, 1-(phenylmethyl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-
[CAS]

1321361-13-0
[Synonyms]

AChE/BChE/BACE-1-IN-1
3-Pyrrolidinamine, 1-(phenylmethyl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-
[Molecular Formula]

C19H21F3N2O
[MOL File]

1321361-13-0.mol
[Molecular Weight]

350.38
Chemical PropertiesBack Directory
[Boiling point ]

395.6±42.0 °C(Predicted)
[density ]

1.24±0.1 g/cm3(Predicted)
[pka]

8.99±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential[1].
[in vivo]

AChE/BChE/BACE-1-IN-1 (Compound 4k) (0-10 mg/kg; p.o.) ameliorates cognitive dysfunction against the scopolamine-induced amnesia model in the Y-maze test[1].

[References]

[1] Choubey PK, et al. Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer's disease. Bioorg Med Chem. 2020 Nov 15;28(22):115721. DOI:10.1016/j.bmc.2020.115721
1321361-13-0 suppliers list
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