| Identification | Back Directory | [Name]
SR 31747 | [CAS]
132173-07-0 | [Synonyms]
SR 31747
HKHPCMBPASXYGP-KVVVOXFISA-N
(Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine
3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine
(Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine hydrochloride
3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine hydrochloride
(Z)-N-[3-(3-CHLORO-4-CYCLOHEXYLPHENYL)PROP-2-ENYL]-N-ETHYLCYCLOHEXYLAMINE HYDROCHLORIDE | [MOL File]
132173-07-0.mol |
| Hazard Information | Back Directory | [Uses]
SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase[1][2]. | [in vivo]
In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED50, 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition[1]. | [References]
[1] Derocq JM, et al. In vivo inhibition of endotoxin-induced pro-inflammatory cytokines production by the sigma ligand SR 31747. J Pharmacol Exp Ther. 1995 Jan;272(1):224-30. PMID:7815336
[2] Silve S, et al. The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Jun;16(6):2719-27. DOI:10.1128/MCB.16.6.2719 |
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