| Identification | Back Directory | [Name]
Hydroxy(2-naphthyl)Methanephosphonic Acid | [CAS]
132541-52-7 | [Synonyms]
Hydroxy(2-naphthyl)Methanephosphonic Acid
P-(Hydroxy-2-naphthalenylMethyl)phosphonic Acid
Phosphonic acid, P-(hydroxy-2-naphthalenylmethyl)- | [Molecular Formula]
C11H11O4P | [MDL Number]
MFCD27943631 | [MOL File]
132541-52-7.mol | [Molecular Weight]
238.18 |
| Chemical Properties | Back Directory | [Melting point ]
>180oC(dec.) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO, Methanol | [form ]
White solid. | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Description]
HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity. It does not affect protein kinase C or cyclic AMP-dependent protein kinase activities. HNMPA inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor with an IC50 value of 200 μM in vitro. | [Uses]
A selective insulin receptor tyrosine kinase inhibitor | [Uses]
Insulin receptor tyrosine kinase (IRTK) inhibitor. | [References]
[1]. baltensperger k, lewis re, woon cw, et al. catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. proc natl acad sci u s a. 1992 sep 1;89(17):7885-9.
[2]. moon mj, kim hy, park s, et al. insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. mol cells. 2011 oct;32(4):389-95. |
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Energy Chemical
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