| Identification | Back Directory | [Name]
15,15'-epoxy-beta,beta-carotene | [CAS]
132541-62-9 | [Synonyms]
beta-carotene 15,15'-epoxide
15,15'-epoxy-beta,beta-carotene | [Molecular Formula]
C40H56O | [MOL File]
132541-62-9.mol | [Molecular Weight]
552.872 |
| Hazard Information | Back Directory | [Uses]
β-carotene-15,15?-epoxide is a XIAP antagonist with apoptosis-inducing and antitumor activity, found in the leaves of Spondias mombin. In a DMBA (HY-W011845)-induced rat model of breast cancer, β-carotene-15,15?-epoxide binds to the BIR3 domain of the anti-apoptotic protein XIAP, blocking its interaction with caspase-9 and thereby promoting tumor cell apoptosis. In addition, β-carotene-15,15?-epoxide significantly downregulates the expression of BCL-2, COX-2, and TNF-α in tumor tissues, reduces MDA levels, increases catalase activity, and modulates serum levels of LDH, ALP, and ALT, demonstrating strong antioxidant, anti-inflammatory, and metabolic protective effects. β-carotene-15,15?-epoxide may be used in research on inflammation-related conditions and cancers such as breast cancer[1]. | [Definition]
ChEBI: An epoxycarotenoid obtained by epoxidation across the 15,15'-double bond of beta-carotene. | [References]
[1] Metibemu DS, et al. Carotenoid isolates of Spondias mombin demonstrate anticancer effects in DMBA-induced breast cancer in Wistar rats through X-linked inhibitor of apoptosis protein (XIAP) antagonism and anti-inflammation. J Food Biochem. 2020 Dec;44(12):e13523. DOI:10.1111/jfbc.13523 |
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