| Identification | Back Directory | [Name]
FlufenaMic acid-13C6 | [CAS]
1325559-30-5 | [Synonyms]
FlufenaMic acid-13C6
Flufenamic acid-(benzoic ring-13C6)
2-(3-Trifluoromethylphenylamino)benzoic-13C6 acid | [Molecular Formula]
C14H10F3NO2 | [MDL Number]
MFCD20036276 | [MOL File]
1325559-30-5.mol | [Molecular Weight]
287.19 |
| Hazard Information | Back Directory | [Uses]
Flufenamic acid-13C6 is the 13C6 labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Guinamard R, et al. Flufenamic acid as an ion channel modulator. Pharmacol Ther. 2013 May;138(2):272-84. DOI:10.1016/j.pharmthera.2013.01.012
[3] Pongkorpsakol P, et al. Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-κB inhibition and AMPK activation. Eur J Pharmacol. 2017 Mar 5;798:94-104. DOI:10.1016/j.ejphar.2017.01.026
[4] Pongkorpsakol P, et al. Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells. J Pharmacol Sci. 2017 Jun;134(2):93-100. DOI:10.1016/j.jphs.2017.05.009
[5] Pobbati AV, et al. Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy. Structure. 2015;23(11):2076-2086. DOI:10.1016/j.str.2015.09.009 |
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