| Chemical Properties | Back Directory | [Boiling point ]
618.5±55.0 °C(predicted) | [density ]
1.344±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
13.70±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
Anticancer agent 223 (Compound V-d) is an anticancer agent that triggers cell death through caspase-dependent and caspase-independent mechanisms. Anticancer agent 223 inhibits tumor spheroid formation and resensitizes cisplatin (HY-17394)-resistant A2780 cells to cisplatin (HY-17394) treatment[1]. | [References]
[1] Thuy Lu Vo T, et al. Design, synthesis and biological evaluation of novel quinazoline derivatives as immune checkpoint inhibitors. Bioorg Med Chem Lett. Published online May 15, 2024. DOI:10.1016/j.bmcl.2024.129796 |
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