| Identification | Back Directory | [Name]
(R)-Simurosertib | [CAS]
1330782-69-8 | [Synonyms]
(R)-TAK-931
TAK931 R-isomer
(R)-Simurosertib
(R) Simurosertib,(R)Simurosertib
6-(3-methyl-1H-pyrazol-4-yl)-2-[(2R)-quinuclidin-2-yl]-3H-thieno[3,2-d]pyrimidin-4-one
Thieno[3,2-d]pyrimidin-4(3H)-one, 2-(2R)-1-azabicyclo[2.2.2]oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)- | [Molecular Formula]
C17H19N5OS | [MDL Number]
MFCD32067867 | [MOL File]
1330782-69-8.mol | [Molecular Weight]
341.43 |
| Chemical Properties | Back Directory | [Boiling point ]
598.3±60.0 °C(Predicted) | [density ]
1.67±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 75 mg/mL (219.66 mM) | [form ]
Solid | [pka]
13.85±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(R)-Simurosertib ((R)-TAK-931) is the (R)-enantiomer of Simurosertib. Simurosertib (TAK-931) is an orally active, selective and ATP-competitive cell division cycle 7 (CDC7) kinase inhibitor, with an IC50 of <0.3 nM [1]. | [References]
[1] K Iwai, et al. A novel CDC7-selective inhibitor TAK-931 with potent antitumor activity. European Journal of Cancer , 2016 , 69 (1) :S34. |
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