| Identification | Back Directory | [Name]
lyngbyatoxin B | [CAS]
133084-52-3 | [Synonyms]
lyngbyatoxin B
3H-Pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one, 9-(1-ethenyl-4-hydroxy-1,5-dimethyl-5-hexenyl)-1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)- (9CI) | [Molecular Formula]
C27H39N3O3 | [MOL File]
133084-52-3.mol | [Molecular Weight]
453.62 |
| Hazard Information | Back Directory | [Description]
Lyngbyatoxin B is an irritant form Lyngbya majuscula. | [Uses]
Lyngbyatoxin B is a complex compound in a versatile biosynthetic pathway from the marine cyanobacterium Moorea producens. By heterologously expressing the lyngbyatoxin biosynthetic pathway in Escherichia coli, lyngbyatoxin A (25.6 mg/L) and its precursor indolactam-V (150 mg/L) were successfully produced. This approach confirmed the biosynthetic route of lyngbyatoxin and laid a chemical foundation for future pathway engineering. In addition, the successful production of lyngbyatoxin A in E. coli opens the possibility for heterologous expression and characterization of other cyanobacterial natural products. | [References]
[1] High-Titer Heterologous Production in E. coli of Lyngbyatoxin, a Protein Kinase C Activator from an Uncultured Marine Cyanobacterium |
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