| Chemical Properties | Back Directory | [Boiling point ]
658.822±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.252±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
8.032±0.19(predicted) |
| Hazard Information | Back Directory | [Uses]
SM1044 is a dihydroartemisinin (DHA) dimer. SM1044 activates caspase, induces apooptosis in RL95-2 and KLE cells. SM1044 inhibits proliferations of cancer cells RL95-2, KLE, HEC-50, HEC-1-A, HEC-1-B, AN3CA, with IC50 < 3.6 μM . SM1044 inhbits tumor growth in RL95-2 xenograft mouse model[1]. | [References]
[1] Zhu Y, et al., Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite. Sci Rep. 2019 Oct 29;9(1):15528. DOI:10.1038/s41598-019-52108-6 |
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