| Identification | Back Directory | [Name]
1H-IMIDAZO[4,5-B]PYRIDINE, 2-ETHYL-5,7-DIMETHYL- | [CAS]
133240-06-9 | [Synonyms]
5,7-DiMethyl-2-ethyliMidazo[4,5-b]pyridine
2-ETHYL-5,7-DIMETHYL-3H-IMIDAZO[4,5-B]PYRIDINE
2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-β]pyridine
2-ethyl-5,7-dimethyl-1H-imidazo[4,5-b]pyridine
1H-IMIDAZO[4,5-B]PYRIDINE, 2-ETHYL-5,7-DIMETHYL- | [Molecular Formula]
C10H13N3 | [MDL Number]
MFCD01632103 | [MOL File]
133240-06-9.mol | [Molecular Weight]
175.23 |
| Chemical Properties | Back Directory | [Appearance]
Off-white powder | [Melting point ]
142-146 °C | [Boiling point ]
279.7±23.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO, Methanol | [form ]
Solid | [pka]
8.89±0.40(Predicted) | [color ]
Pale Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white powder | [Uses]
2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is used as building block in chemical synthesis. Attributes Development Product Contact | [Description]
2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is a nonpeptidic angiotensin II receptor antagonist whose imidazo[4,5-b]pyridine scaffold has been used to examine a variety of positional substitutions in the development of orally active, long duration antihypertensive agents. | [Synthesis Reference(s)]
Tetrahedron Letters, 35, p. 5775, 1994 DOI: 10.1016/S0040-4039(00)78181-0 | [in vitro]
in a previous study, 2-ethyl-5,7-dimethyl-3h-imidazo[4,5-b]pyridine was synthezed by reduction of 2-amino-3-nitropyridine derivatives to the corresponding diaminopyridine which was then condensed with an appropriate carboxylic acid in polyphosphoric acid. in vitro activity study showed that 2-ethyl-5,7-dimethyl-3h-imidazo[4,5-b]pyridine was a nonpeptidic angiotensin ii receptor antagonist whose imidazo[4,5-b]pyridine scaffold had been used to examine plenty of positional substitutions in the development of orally active, long duration antihypertensive agents [1]. | [References]
[1] mantlo, n. b.,chakravarty, p.k.,ondeyka, d.l., et al. potent, orally active imadazo[4,5-b]pyridine-based angiotensin ii receptor antagonists. journal of medicinal chemistry 34(9), 2919-2922 (1991). |
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