| Identification | Back Directory | [Name]
FEDOTOZINE D(-)-TARTRATE | [CAS]
133267-27-3 | [Synonyms]
FEDOTOZINE TARTRATE
FEDOTOZINE D(-)-TARTRATE
(2S,3S)-2,3-dihydroxybutanedioic acid,(2R)-N,N-dimethyl-2-phenyl-1-[(3,4,5-trimethoxyphenyl)methoxy]butan-2-amine | [Molecular Formula]
C22H31NO4.C4H6O6 | [MOL File]
133267-27-3.mol | [Molecular Weight]
523.575 |
| Chemical Properties | Back Directory | [Melting point ]
147° | [alpha ]
D25 +14.5° (c = 5 in HCl) | [solubility ]
DMSO: Sparingly soluble: 1-10 mg/ml
Water: Slightly soluble: 0.1-1 mg/ml |
| Hazard Information | Back Directory | [Description]
Fedotozine is a κ-opioid receptor agonist.1 It binds to κ-opioid receptors in mouse brain membranes (Ki = 0.16 nM). In vivo, fedotozine (10 mg/kg) reduces gastric extension-induced increases in mean arterial pressure (MAP), a marker for hyperalgesia, in a rat model of duodenal acidification-induced gastric hypersensitivity.2 It also prevents colonic distension-induced inhibition of gastric motility and emptying in dogs when administered at a dose of 50 µg/kg.3WARNING This product is not for human or veterinary use. | [References]
[1] J LAI. Pharmacological characterization of the cloned kappa opioid receptor as a kappa 1b subtype.[J]. Neuroreport, 1994, 5 16: 2161-2164. DOI: 10.1097/00001756-199410270-00043
[2] MARI NAKATA-FUKUDA . Inhibitory effect of the selective serotonin 5-HT3 receptor antagonist ramosetron on duodenal acidification-induced gastric hypersensitivity in rats[J]. European journal of pharmacology, 2014, 731: Pages 88-92. DOI: 10.1016/j.ejphar.2014.02.040
[3] MICHÈLE GUÉ Lionel B Jean Louis Junien. The κ agonist fedotozine modulates colonic distention-induced inhibition of gastric motility and emptying in dogs[J]. Gastroenterology, 1994, 107 5: Pages 1327-1334. DOI: 10.1016/0016-5085(94)90534-7 |
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