| Identification | Back Directory | [Name]
Biotin-Teg-Nh2 Tfa | [CAS]
1334172-59-6 | [Synonyms]
CAS_1334172-59-6
Biotin-Teg-Nh2 Tfa
Biotin-dPEG??-NH?+TFA-
Biotin-C1-PEG3-C3-amine TFA
1H-Thieno[3,4-d]imidazol-2(3H)-one, 4-[8-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]-5-oxooctyl]tetrahydro-, (3aS,4S,6aR)-, 2,2,2-trifluoroacetate (1:1) | [Molecular Formula]
C20H38N4O5S.C2HF3O2 | [MDL Number]
MFCD13184983 | [MOL File]
1334172-59-6.mol | [Molecular Weight]
545.62 |
| Hazard Information | Back Directory | [Biological Activity]
Biotin-C1-PEG3-C3-amine (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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