| Identification | Back Directory | [Name]
BNP-32 (RAT) | [CAS]
133448-20-1 | [Synonyms]
BNP RAT
BNP-32 (RAT)
BNP (1-32) RAT
BNP (51-95), RAT
BNP-32 (rat) trifluoroacetate
NSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF
BRAIN NATRIURETIC PEPTIDE-32 (RAT)
Rat brain natriuretic peptide(1-32)
BRAIN NATRIURETIC PEPTIDE (1-32), RAT
14-45-Brain natriuretic peptide-45 (rat)
B-TYPE (BRAIN) NATRIURETIC PEPTIDE-32 (RAT)
Brain Natriuretic Peptide (BNP) (1-32), rat
Brain natriuretic peptide-32 rat, ≥97% (HPLC)
14-45-Brain natriuretic peptide-45 (rat) (9CI)
BNP-32 (rat)
Brain Natriuretic Peptide-32 (rat)
Brain Natriuretic Peptide-32 rat >=97% (HPLC), powder
NSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF (DISULFIDE BRIDGE: 10-26)
ASN-SER-LYS-MET-ALA-HIS-SER-SER-SER-CYS-PHE-GLY-GLN-LYS-ILE-ASP-ARG-ILE-GLY-ALA-VAL-SER-ARG-LEU-GLY-CYS-ASP-GLY-LEU-ARG-LEU-PHE
H-ASN-SER-LYS-MET-ALA-HIS-SER-SER-SER-CYS-PHE-GLY-GLN-LYS-ILE-ASP-ARG-ILE-GLY-ALA-VAL-SER-ARG-LEU-GLY-CYS-ASP-GLY-LEU-ARG-LEU-PHE-OH
H-ASN-SER-LYS-MET-ALA-HIS-SER-SER-SER-CYS-PHE-GLY-GLN-LYS-ILE-ASP-ARG-ILE-GLY-ALA-VAL-SER-ARG-LEU-GLY-CYS-ASP-GLY-LEU-ARG-LEU-PHE-OH, (DISULFIDE BOND)
H-ASN-SER-LYS-MET-ALA-HIS-SER-SER-SER-CYS-PHE-GLY-GLN-LYS-ILE-ASP-ARG-ILE-GLY-ALA-VAL-SER-ARG-LEU-GLY-CYS-ASP-GLY-LEU-ARG-LEU-PHE-OH (DISULFIDE BRIDGE: 10-26)
ASN-SER-LYS-MET-ALA-HIS-SER-SER-SER-CYS-PHE-GLY-GLN-LYS-ILE-ASP-ARG-ILE-GLY-ALA-VAL-SER-ARG-LEU-GLY-CYS-ASP- GLY-LEU-ARG-LEU-PHE(DISULFIDE BRIDGE:CYS10-CYS26)
L-Asn-L-Ser-L-Lys-L-Met-L-Ala-L-His-L-Ser-L-Ser-L-Ser-L-Cys(1)-L-Phe-Gly-L-Gln-L-Lys-L-Ile-L-Asp-L-Arg-L-Ile-Gly-L-Ala-L-Val-L-Ser-L-Arg-L-Leu-Gly-L-Cys(1)-L-Asp-Gly-L-Leu-L-Arg-L-Leu-L-Phe-OH | [Molecular Formula]
C146H239N47O44S3 | [MDL Number]
MFCD00133150 | [MOL File]
133448-20-1.mol | [Molecular Weight]
3452.94 |
| Chemical Properties | Back Directory | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
powder
| [Water Solubility ]
Soluble in Water | [Sequence]
Asn-Ser-Lys-Met-Ala-His-Ser-Ser-Ser-Cys-Phe-Gly-Gln-Lys-Ile-Asp-Arg-Ile-Gly-Ala-Val-Ser-Arg-Leu-Gly-Cys-Asp-Gly-Leu-Arg-Leu-Phe (Disulfide bridge: Cys10-Cys26) |
| Hazard Information | Back Directory | [Uses]
Brain Natriuretic Peptide (1-32), rat (BNP (1-32), rat) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes)[1]. | [Biochem/physiol Actions]
Brain natriuretic peptide (type B natriuretic peptide) was originally isolated from brain, but is mainly produced in myoendocrine cells of the heart ventricles from which it is released into the circulation. It is involved in blood pressure control and cardiovascular homeostasis. | [in vivo]
The depressor, natriuretic and cyclic GMP responses to several species of brain natriuretic peptide (BNP) are compared to atrial natriureticpeptide (ANP) 99-126 in conscious spontaneously hypertensive rats (SHR) and in conscious cynomolgus monkeys treated with vehicle or the selective neutral endopeptidase inhibitor SQ 28603. In the conscious SHR, the natriuretic and cyclic GMP responses to 3 nmol/kg i.v. rat BNP (1-32) greater than rat ANP 99-126 greater than pig BNP-26 and sre significantly potentiated by 100 mumol/kg i.v. SQ 28,603. Human BNP-32 is inactive in the SHR treated with either vehicle or SQ 28,603. In contrast, 1 nmol/kg i.v. of human BNP (1-32) stimulates renal and depressor responses in the conscious monkeys that are greater than or equal to those elicited by human ANP 99-126, whereas 3 nmol/kg i.v. rat BNP (1-32) reduces mean arterial pressure without affecting renal function[3]. | [storage]
Store at -20°C | [References]
[1] Dickey DM, et al. Human B-type natriuretic peptide is not degraded by meprin A. Biochem Pharmacol. 2010 Oct 1;80(7):1007-11. DOI:10.1016/j.bcp.2010.06.015
[2] Wellard J, et al. Natriuretic peptides, but not nitric oxide donors, elevate levels of cytosolic guanosine 3',5'-cyclic monophosphate in ependymal cells ex vivo. Neurosci Lett. 2006 Jan 16;392(3):187-92. DOI:10.1016/j.neulet.2005.09.084
[3] Seymour AA, et al. Potentiation of brain natriuretic peptides by SQ 28,603, an inhibitor of neutral endopeptidase3.4.24.11, in monkeys and rats. J Pharmacol Exp Ther. 1992 Jul;262(1):60-70. PMID:1385630 |
|
|