| Identification | Back Directory | [Name]
Q203 | [CAS]
1334719-95-7 | [Synonyms]
Q203
IAP6
IAP-6
IAP 6
CS-2499
Telacebec
Q203（IAP6）
Q-203;Q 203;IAP 6;IAP-6;IAP6
6-CHLORO-2-ETHYL-N-(4-(4-(4-(TRIFLUOROMETHOXY)PHENYL)PIPERIDIN-1-YL)BENZYL)IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDE
6-chloro-2-ethyl-N-[(4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methyl]imidazo[1,2-a]pyridine-3-carboxamide
Imidazo[1,2-a]pyridine-3-carboxamide, 6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]-1-piperidinyl]phenyl]methyl]- | [Molecular Formula]
C29H28ClF3N4O2 | [MDL Number]
MFCD28502122 | [MOL File]
1334719-95-7.mol | [Molecular Weight]
557.01 |
| Chemical Properties | Back Directory | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 16 mg/ml; DMSO: 14 mg/ml; Ethanol: Slightly soluble | [form ]
A solid | [pka]
12.29±0.46(Predicted) | [color ]
White to off-white | [InChIKey]
OJICYBSWSZGRFB-UHFFFAOYSA-N | [SMILES]
C12=NC(CC)=C(C(NCC3=CC=C(N4CCC(C5=CC=C(OC(F)(F)F)C=C5)CC4)C=C3)=O)N1C=C(Cl)C=C2 |
| Hazard Information | Back Directory | [Uses]
Telacebec (Q203) is a midazopyridine amide compound. Telacebec is active against Mycobacterium tuberculosis H37Rv with an MIC50 of 2.7 nM in culture broth medium. | [in vivo]
Telacebec (Q203) is efficacious in a mouse model of tuberculosis at a dose less than 1 mg per kg body weight. Telacebec displays pharmacokinetic and safety profiles compatible with once-daily dosing. Telacebec has a bioavailability of 90% and a terminal half-life of 23.4 h. The volume of distribution is moderate (5.27 l per kg body weight), and the systemic clearance is low (4.03 mL/min per kg). After 4 weeks of treatment, reductions of 90%, 99% and 99.9% in M. tuberculosis H37Rv bacterial load is observed in the groups treated with Telacebec at 0.4, 2 and 10 mg per kg body weight, respectively[1]. | [References]
[1] Pethe K, et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat Med. 2013 Sep;19(9):1157-60. DOI:10.1038/nm.3262 |
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