| Identification | Back Directory | [Name]
TYRPHOSTIN AG 538 | [CAS]
133550-18-2 | [Synonyms]
AG 538 - CAS 133550-18-2 - Calbiochem
(E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
(αe)-α-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-benzenepropanenitrile
Benzenepropanenitrile, α-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-, (αE)-
AG 538, (αE)-α-[(3,4-Dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-benzenepropanenitrile | [Molecular Formula]
C16H11NO5 | [MDL Number]
MFCD03453581 | [MOL File]
133550-18-2.mol | [Molecular Weight]
297.26 |
| Chemical Properties | Back Directory | [Boiling point ]
637.5±55.0 °C(Predicted) | [density ]
1.538±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO: 5mg/mL | [form ]
solid | [pka]
7.48±0.35(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM[1]. | [Definition]
ChEBI: 3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphenyl)-oxomethyl]-2-propenenitrile is a member of chalcones. | [Biological Activity]
Cell permeable: yes''Primary Target
IGF-1 receptor kinase''Product competes with ATP.''Reversible: yes''Target IC50: 400 nM against IGF-1 receptor kinase | [References]
[1] G Blum, et al. Substrate Competitive Inhibitors of IGF-1 Receptor Kinase. Biochemistry. 2000 Dec 26;39(51):15705-12. DOI:10.1021/bi001516y |
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Merck Millipore
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Merck KGaA
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SIGMA-RBI
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