| Identification | Back Directory | [Name]
CHROMOGRANIN A (124-143) (BOVINE) | [CAS]
133633-11-1 | [Synonyms]
CHROMOSTATIN
CHROMOSTATIN-20
Chromostatin (ox)
CHROMOSTATIN, BOVINE
SDEDSDGDRPQASPGLGPGP
CHROMOSTATIN-20, BOVINE
CHROMOGRANIN A (124-143) (BOVINE)
ChroMostatin
ChroMogranin A (124-143) (bovine)
SER-ASP-GLU-ASP-SER-ASP-GLY-ASP-ARG-PRO-GLN-ALA-SER-PRO-GLY-LEU-GLY-PRO-GLY-PRO
H-SER-ASP-GLU-ASP-SER-ASP-GLY-ASP-ARG-PRO-GLN-ALA-SER-PRO-GLY-LEU-GLY-PRO-GLY-PRO-OH
SER-ASP-GLU-ASP-SER-ASP-GLY-ASP-ARG-PRO-GLN-ALA-SER-PRO-GLY-LEU-GLY-PRO-GLY-PRO: SDEDSDGDRPQASPGLGPGP
L-Proline, L-seryl-L-α-aspartyl-L-α-glutamyl-L-α-aspartyl-L-seryl-L-α-aspartylglycyl-L-α-aspartyl-L-arginyl-L-prolyl-L-glutaminyl-L-alanyl-L-seryl-L-prolylglycyl-L-leucylglycyl-L-prolylglycyl- | [Molecular Formula]
C78H120N24O35 | [MDL Number]
MFCD00143974 | [MOL File]
133633-11-1.mol | [Molecular Weight]
1953.93 |
| Hazard Information | Back Directory | [Uses]
Chromostatin bovine is a chromogranin A (CGA) derivative peptide, which inhibits postassium or carbamoylcholine induced catecholamine release with an ID50 of 5 nM. Chromostatin bovine reduces calcium flux, enhances the desensitization process of the cholinergic-evoked secretory response and modulates the endocrine response associated with catecholamine[1]. | [References]
[1] Galindo E, et al., Chromostatin, a 20-amino acid peptide derived from chromogranin A, inhibits chromaffin cell secretion. Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1426-30. DOI:10.1073/pnas.88.4.1426 |
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