| Identification | Back Directory | [Name]
4-Quinolinecarboxylic acid, 2-(4-butoxy-3-methoxyphenyl)- | [CAS]
133676-47-8 | [Synonyms]
hDHODH-IN-9
4-Quinolinecarboxylic acid, 2-(4-butoxy-3-methoxyphenyl)- | [Molecular Formula]
C21H21NO4 | [MOL File]
133676-47-8.mol | [Molecular Weight]
351.4 |
| Hazard Information | Back Directory | [Uses]
hDHODH-IN-9 (Compound 3k) is a potent inhibitor of hDHODH with an IC50 of 0.34 μM. hDHODH-IN-9 demonstrates high cytotoxic activity against MCF-7 and A375 cells and good selectivity. hDHODH-IN-9 has the potential for the research of cancer diseases[1]. | [References]
[1] Petrovi? MM, et al. Potent human dihydroorotate dehydrogenase inhibitory activity of new quinoline-4-carboxylic acids derived from phenolic aldehydes: Synthesis, cytotoxicity, lipophilicity and molecular docking studies. Bioorg Chem. 2020;105:104373. DOI:10.1016/j.bioorg.2020.104373 |
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