| Identification | Back Directory | [Name]
Ethanol, 2-[2-[2-(triphenylmethoxy)ethoxy]ethoxy]- | [CAS]
133699-09-9 | [Synonyms]
Tr-PEG4
Tr-PEG3-OH
2-(2-(2-(trityloxy)ethoxy)ethoxy)ethanol
2-(2-(2-(trityloxy)ethoxy)ethoxy)ethanol(WXPC0041)
Ethanol, 2-[2-[2-(triphenylmethoxy)ethoxy]ethoxy]- | [Molecular Formula]
C25H28O4 | [MDL Number]
MFCD22574815 | [MOL File]
133699-09-9.mol | [Molecular Weight]
392.49 |
| Chemical Properties | Back Directory | [Boiling point ]
521.8±45.0 °C(Predicted) | [density ]
1.126±0.06 g/cm3(Predicted) | [form ]
Viscous Liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Tr-PEG4 is a PEG linker containing a trityl, alcohol protecting group and a terminal hydroxyl group. Trityl can be removed under acidic conditions. The hydroxyl group can undergo various reactions in order to further derivatize the compound. The hydrophilic PEG linkers increase the solubility of compounds in aqueous media. | [Uses]
Tr-PEG3-OH is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). | [References]
[1] Chou CH, et al. Glycan-Directed Grafting-from Polymerization of Immunoglobulin G: Site-Selectively Modified IgG-Polymer Conjugates with Preserved Biological Activity. Biomacromolecules. 2018 Jul 9;19(7):3086-3095. DOI:10.1016/s0950-3528(98)90140-3 |
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