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133737-32-3

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133737-32-3 Structure

133737-32-3 Structure
IdentificationBack Directory
[Name]

PAGOCLONE
[CAS]

133737-32-3
[Synonyms]

Ip 456
CI-1043
AGOCLONE
Rp 62955
RP 59037
(+)-RP-59037; IP-456; RP-62955; CI-1043
2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone
2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-Methyl-2-oxohexyl)isoindolin-1-one
[EINECS(EC#)]

225-799-5
[Molecular Formula]

C23H22ClN3O2
[MDL Number]

MFCD00864700
[MOL File]

133737-32-3.mol
[Molecular Weight]

407.899
Chemical PropertiesBack Directory
[Boiling point ]

582.1±50.0 °C(Predicted)
[density ]

1.273±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

1.62±0.30(Predicted)
[color ]

White to off-white
[InChI]

InChI=1S/C23H22ClN3O2/c1-14(2)7-10-16(28)13-19-17-5-3-4-6-18(17)23(29)27(19)21-12-9-15-8-11-20(24)25-22(15)26-21/h3-6,8-9,11-12,14,19H,7,10,13H2,1-2H3
[InChIKey]

HIUPRQPBWVEQJJ-UHFFFAOYSA-N
[SMILES]

C1(=O)C2=C(C=CC=C2)C(CC(=O)CCC(C)C)N1C1=CC=C2C(=N1)N=C(Cl)C=C2
Hazard InformationBack Directory
[Description]

Pagoclone is a drug that belongs to the class of cyclopyrrolones. It binds to the benzodiazepine binding site on GABAA receptors and acts as a negative allosteric modulator, thereby enhancing the inhibitory effects of GABA and reducing neuronal excitability.
[Uses]

Anti-anxiety agent.
[Application]

Pagoclone has been shown to have anti-inflammatory properties in an animal model of inflammatory bowel disease and may be useful for the treatment of this condition.
[Brand name]

Bextra (Interneuron).
Spectrum DetailBack Directory
[Spectrum Detail]

PAGOCLONE(133737-32-3)1HNMR
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