| Identification | Back Directory | [Name]
Vatanidipine hydrochloride | [CAS]
133743-71-2 | [Synonyms]
Vatanidipine hydrochloride
Watanidipine dihydrochloride | [Molecular Formula]
C41H42N4O6.2HCl | [MDL Number]
MFCD00891526 | [MOL File]
133743-71-2.mol | [Molecular Weight]
723.27 |
| Safety Data | Back Directory | [Safety Profile]
A poison by ingestion,
intraperitoneal, and subcutaneous routes.
When heated to decomposition it emits
toxic vapors of NOx. |
| Hazard Information | Back Directory | [Uses]
Vatanidipine (Watanidipine) hydrochloride is an orally active dihydropyridine (DHP)-type calcium channel blocker and a useful antihypertensive agent. Vatanidipine hydrochloride shows vasodilatory effects and also suppresses noradrenaline release from sympathetic nerve endings[1][2]. | [Definition]
ChEBI: Vatanidipine hydrochloride is a diarylmethane. | [in vivo]
Vatanidipine (1-10 mg/kg, p.o.) suppresses the systolic blood pressure of spontaneously hypertensive rats[1].
| [References]
[1] Matsumura Y, et al. Vatanidipine hydrochloride: a new long-lasting antihypertensive agent. Expert Opin Investig Drugs. 2001 Jan;10(1):139-55. DOI:10.1517/13543784.10.1.139
[2] H Shinyama, et al. Effects of the calcium antagonist AE0047 on the development of neurological deficit and infarction after middle cerebral artery occlusion in stroke-prone spontaneously hypertensive rats. J Pharm Pharmacol. 1997 Sep;49(9):919-24. DOI:10.1111/j.2042-7158.1997.tb06136.x |
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