| Identification | Back Directory | [Name]
3-(4-pyridinyl)-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazole 3-(Pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | [CAS]
133847-06-0 | [Synonyms]
YU142670
YU142670 >=98% (HPLC)
1,2,4-Triazolo[3,4-b][1,3,4]thiadiazole, 3-(4-pyridinyl)-
3-(4-pyridinyl)-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazole 3-(Pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | [Molecular Formula]
C8H5N5S | [MOL File]
133847-06-0.mol | [Molecular Weight]
203.22 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear (warmed) | [form ]
powder | [color ]
white to light brown | [InChIKey]
HRBYAJQMVADJHW-UHFFFAOYSA-N | [SMILES]
C12=NN=C(C3=CC=NC=C3)N1N=CS2 |
| Hazard Information | Back Directory | [Description]
YU142670 is a novel selective inhibitor against OCRL1/INPP5F and OCRL2/INPP5B by targeting OCRL catalytic domain. | [Uses]
YU142670 is an inhibitor of OCRL/INPP5B with IC50 values of 0.71 μM and 1.78 μM respectively[1]. | [References]
[1] Mills SJ, et al. Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family. Biochemistry. 2016 Mar 8;55(9):1384-97. DOI:10.1021/acs.biochem.5b00838 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|