| Identification | Back Directory | [Name]
2-[2-[2-[2-[(tert-Butyldimethylsilanyl)oxy]ethoxy]ethoxy]ethoxy]ethanol | [CAS]
134179-40-1 | [Synonyms]
TBDMS-PEG5
TBDMS-PEG4-OH
TBDMS-PEG4-alcohol
2-[2-(2-TBDMSO-ethoxy)ethoxy]ethoxy]ethanol
2,2,3,3-Tetramethyl-4,7,10,13-tetraoxa-3-silapentadecan-15-ol
13,13,14,14-Tetramethyl-3,6,9,12-tetraoxa-13-sila-1-pentadecanol
3,6,9,12-Tetraoxa-13-silapentadecan-1-ol, 13,13,14,14-tetramethyl-
13,13,14,14-Tetramethyl-3,6,9,12-tetraoxa-13-sila-1-pentadecanol 97%
2-[2-[2-[2-[(tert-Butyldimethylsilanyl)oxy]ethoxy]ethoxy]ethoxy]ethanol | [Molecular Formula]
C14H32O5Si | [MDL Number]
MFCD25424114 | [MOL File]
134179-40-1.mol | [Molecular Weight]
308.49 |
| Chemical Properties | Back Directory | [density ]
0.959 g/mL at 25 °C | [refractive index ]
n20/D1.447 | [Fp ]
>110℃ | [storage temp. ]
Storage temp. 2-8°C | [form ]
Liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to light yellow | [Boiling point ]
330-338°C/760 mmHg | [InChI]
InChI=1S/C14H32O5Si/c1-14(2,3)20(4,5)19-13-12-18-11-10-17-9-8-16-7-6-15/h15H,6-13H2,1-5H3 | [InChIKey]
KZFZMISGZPOLJM-UHFFFAOYSA-N | [SMILES]
C(O)COCCOCCOCCO[Si](C)(C)C(C)(C)C |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301-H315 | [Precautionary statements ]
P301+P310+P330-P302+P352 | [Hazard Codes ]
T | [Risk Statements ]
25-38 | [Safety Statements ]
45 | [RIDADR ]
UN 2810 6.1 / PGIII | [WGK Germany ]
3 | [Storage Class]
6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Description]
TBDMS-PEG5 is a PEG linker containing a TBDMS alcohol protecting group and a terminal hydroxyl group. TBDMS can be removed in the presence of acetyl chloride. The terminal hydroxyl group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of compounds in aqueous environments. | [Uses]
TBDMS-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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