| Identification | Back Directory | [Name]
S-(E-1,2-DICHLOROVINYL)-L-CYSTEINE | [CAS]
13419-46-0 | [Synonyms]
S-[(1E)-1
DCVC (E-isomer)
2-dichloroethenyl]--L-cysteine
S-[(1E)-1;2-DICHLOROETHENYL]--L-CYSTEINE
L-Cysteine, S-[(1E)-1,2-dichloroethenyl]-
DCVC
(S-[(1E)-1,2-dichloroethenyl]--L-cysteine)
2-amino-3-[(E)-1,2-dichloroethenyl]sulfanylpropanoic acid | [Molecular Formula]
C5H7Cl2NO2S | [MOL File]
13419-46-0.mol | [Molecular Weight]
216.09 |
| Chemical Properties | Back Directory | [Melting point ]
155-156 °C (decomp) | [Boiling point ]
339.7±42.0 °C(Predicted) | [density ]
1.437 (estimate) | [refractive index ]
1.6100 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 23 mg/mL (106.44 mM);Water : 1.034 mg/mL (4.79 mM) | [form ]
Solid | [pka]
2.01±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures[1][2]. | [storage]
Store at -20°C | [References]
[1] Boldenow E, et al. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro. Reprod Toxicol. 2015 Apr;52:1-6. DOI:10.1016/j.reprotox.2015.01.007
[2] Lash LH, et al. Multigenerational study of chemically induced cytotoxicity and proliferation in cultures of human proximal tubular cells. Int J Mol Sci. 2014 Nov 18;15(11):21348-65. DOI:10.3390/ijms151121348 |
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