| Identification | Back Directory | [Name]
Acid-PEG5-NHS ester | [CAS]
1343476-41-4 | [Synonyms]
COOH-PEG5-NHS
COOH-PEG5-SPA
Acid-PEG5-NHS ester
COOH-PEG5-NHS ester
Acid-dPEG??-NHS ester
Acid-C2-PEG4-C2-NHS ester
4,7,10,13,16-Pentaoxanonadecanedioic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester | [Molecular Formula]
C18H29NO11 | [MDL Number]
MFCD27952888 | [MOL File]
1343476-41-4.mol | [Molecular Weight]
435.42 |
| Chemical Properties | Back Directory | [Boiling point ]
574.8±60.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Acid-PEG5-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Uses]
Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Nextpeptide Inc
|
| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
| Company Name: |
Wuhan Topule
|
| Telephone: |
+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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