134377-69-8

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134377-69-8 Structure

Identification	Back Directory
[Name] Safironil
[CAS] 134377-69-8
[Synonyms] Safironil 2,4-Pyridinedicarboxamide, N2,N4-bis(3-methoxypropyl)-
[Molecular Formula] C15H23N3O4
[MOL File] 134377-69-8.mol
[Molecular Weight] 309.36

Hazard Information	Back Directory
[Uses] Safironil is an antifibrotic compound. Safironil is a competitive inhibitor of collagen protein synthesis. Safironil reduces liver fibrogenesis by inhibiting HSC activation[1][2].
[References] [1] NO Al-Harbi, et al. Reversal of Liver Fibrosis in Chronic Murine Schistosomiasis mansoni by Safironil/Praziquantel. Tropical Journal of Pharmaceutical Research. Vol. 11 No. 4 (2012) [2] Wang YJ, et al. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females. Am J Pathol. 1998 Jan;152(1):279-87. PMID:9422545

Spectrum Detail	Back Directory
[Spectrum Detail] Safironil(134377-69-8)¹HNMR

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