| Identification | Back Directory | [Name]
Dexelvucitabine | [CAS]
134379-77-4 | [Synonyms]
RVT
YZ 817
D-D-4FC
DPC-817
Reverset
INCB 8721
RA 131423
beta-D-D-4FC
Dexelvucitabine
2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine
Cytidine,2',3'-didehydro-2',3'-dideoxy-5-fluoro-
5-Fluoro-1-(2',3'-dideoxy-2',3'-didehydro-b-D-arabinofuranosyl)-cytosine
4-AMINO-5-FLUORO-1-[(2R,5S)-5-(HYDROXYMETHYL)-2,5-DIHYDROFURAN-2-YL]PYRIMIDIN-2(1H)-ONE
2’,3’-Dideoxy-2’,3’-didehydro-5-fluoro-cytidine, FddddC, Dexelvucitabine (DFC), Reverset
5-Fluoro-1-(2’,3’-dideoxy-2’,3’-didehydro-β-D-arabinofuranosyl)-cytosine (Dexelvucitabine)
Inhibitor,thymidine,Human immunodeficiency virus,d-d4FC,cytidine,M184V mutation,antiretroviral,inhibit,Reverset,2′-deoxycytidine,viral polymerase,Dexelvucitabine,HIV,resistant viruse,nucleoside reverse transcriptase,HIV-1,Reverse Transcriptase | [Molecular Formula]
C9H10FN3O3 | [MDL Number]
MFCD09954118 | [MOL File]
134379-77-4.mol | [Molecular Weight]
227.19 |
| Chemical Properties | Back Directory | [Boiling point ]
394.9±52.0 °C(Predicted) | [density ]
1.66±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM) | [form ]
Solid | [pka]
14.28±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Dexelvucitabine is a nucleoside reverse transcriptase inhibitor (NRTI) which had the potential to inhibit HIV-1 replication. The drug was discontinued due to evidence that it causes damage to the pancreas. | [Uses]
Treatment of HIV-1 and HIV-2 infection. | [Brand name]
Reverset (Incyte). | [in vivo]
Dexelvucitabine (Reverset; d-d4FC; 33.3 mg/kg by i.v. or p.o.) has distribution and elimination half-lives (t1/2α?and?t1/2β, respectively) of 0.7 and 3.6 h in monkeys, respectively. The Cmax ranges from 21.1 to 47.5 μM[2].
Dexelvucitabine has a favorable pharmacokinetic profile with a long half-life (4.71 and 10.75 h after administration by the intravenous [i.v.] and oral [p.o.] routes, respectively)?in woodchucks[2].
| [IC 50]
HIV-1 |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
T&W GROUP
|
| Tel: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList1701258/0_EN.htm |
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