| Identification | Back Directory | [Name]
azaline | [CAS]
134457-26-4 | [Synonyms]
azaline
Azaline A
D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N6-(3-amino-1H-1,2,4-triazol-5-yl)-L-lysyl-N6-(3-amino-1H-1,2,4-triazol-5-yl)-D-lysyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl- | [Molecular Formula]
C74H106ClN23O12 | [MOL File]
134457-26-4.mol | [Molecular Weight]
1545.23 |
| Hazard Information | Back Directory | [Description]
Azaline is a gonadorelin antagonist. | [Uses]
Azaline (Azaline A) is a gonadotropin-releasing hormone (GnRH) receptor antagonist with a KD value of 0.48 nM. Azaline can effectively induce histamine release, with an effect comparable to that of GnRH, and it can completely inhibit ovulation at a dose of 2.0-3.0 μg per female rat. Azaline has potential applications in regulating reproductive functions[1]. | [References]
[1] Rivier J, et al. Gonadotropin releasing hormone antagonists: novel structures incorporating N omega-cyano modified guanidine moieties. Biochem Biophys Res Commun. 1991 Apr 15;176(1):406-12. DOI:10.1016/0006-291x(91)90939-5 |
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