| Identification | Back Directory | [Name]
RC 33 HCl | [CAS]
1346016-43-0 | [Synonyms]
RC33 HCl
RC-33 HCl
RC 33 HCl
RC33 Hydrochloride
RC-33 Hydrochloride
RC 33 Hydrochloride | [Molecular Formula]
C21H28ClN | [MOL File]
1346016-43-0.mol | [Molecular Weight]
329.91 |
| Hazard Information | Back Directory | [Description]
RC-33 HCl is a highly potent, selective, and metabolically stable σ1 receptor agonist potentiating NGF-induced neurite outgrowth. | [Uses]
RC-33 hydrochloride is a selective and metabolically stable σ? receptor agonist with activity in enhancing nerve growth factor (NGF)-induced neurite outgrowth. Both enantiomers of RC-33 hydrochloride bind to the σ? receptor with similar affinity and show almost equal effectiveness as σ? receptor agonists. The R-configured enantiomer of RC-33 hydrochloride shows higher liver metabolic stability in the presence of NADPH. RC-33 hydrochloride was selected as the best candidate for further in vivo studies in animal models of amyotrophic lateral sclerosis[1]. | [References]
[1] Chemical, pharmacological, and in vitro metabolic stability studies on enantiomerically pure RC-33 compounds: promising neuroprotective agents acting as σ? receptor agonists |
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