| Identification | Back Directory | [Name]
6-Quinolinesulfonamide, N-(3-chloro-4-fluorophenyl)-7-fluoro-1,2,3,4-tetrahydro-2-oxo- | [CAS]
1346113-84-5 | [Synonyms]
PKM2 activator 3
6-Quinolinesulfonamide, N-(3-chloro-4-fluorophenyl)-7-fluoro-1,2,3,4-tetrahydro-2-oxo- | [Molecular Formula]
C15H11ClF2N2O3S | [MOL File]
1346113-84-5.mol | [Molecular Weight]
372.77 |
| Chemical Properties | Back Directory | [density ]
1.564±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 100mg/mL, clear, colorless | [form ]
powder | [pka]
7.02±0.20(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
PKM2 activator 3 is a potent PKM2 activator with an AC50 value of 90 nM. PKM2 activator 3 has good Caco-2 permeability, a low efflux ratio and high microsomal stability. PKM2 activator 3 can be used for researching anticancer[1].
(AC50:?the concentration which gives 50% activation of enzyme.) | [in vivo]
PKM2 activator 3 (compound 66) has good Caco-2 permeability, a low efflux ratio (0.84) and high microsomal stability (t1/2 = 277.2 min in human liver microsomes and 117.5 min in mouse liver microsomes)[1]. | [References]
[1] Walsh MJ, et al. 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6322-7. DOI:10.1016/j.bmcl.2011.08.114 |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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