| Identification | Back Directory | [Name]
CANDESARTAN-D4 | [CAS]
1346604-70-3 | [Synonyms]
CV-11974-d4
CANDESARTAN-D4
[2H4]-Candesartan
Candesartan M1-d4
2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1-(phenyl-d4)-1'-phenyl]-4-yl]Methyl]-1H-benziMidazole-7-carboxylic Acid | [Molecular Formula]
C24H16D4N6O3 | [MDL Number]
MFCD08063415 | [MOL File]
1346604-70-3.mol | [Molecular Weight]
444.48 |
| Chemical Properties | Back Directory | [Melting point ]
151-157°C | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Description]
Candesartan-d4 is intended for use as an internal standard for the quantification of candesartan by GC- or LC-MS. Candesartan is an antagonist of the angiotensin II type 1 (AT1) receptor (Kis = 0.17, 0.12, and 0.12 nM for human AT1, rat AT1A, and rat AT1B recombinant receptors, respectively) and an active metabolite of the prodrug candesartan cilexitil (Item No. 10489). It is selective for AT1 over AT2 receptors (Ki = 26,500 nM for the human recombinant AT2 receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID50 = 0.033 mg/kg). Formulations containing candesartan have been used in the treatment of hypertension and heart failure. | [Chemical Properties]
CANDESARTAN-D4 is White to Off-White Solid
| [Uses]
CANDESARTAN-D4 is an angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive.
| [References]
[1] Y. INADA S. C T Nakane*. Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors[J]. Fundamental & Clinical Pharmacology, 2002, 16 4: 317-323. DOI: 10.1046/j.1472-8206.2002.00076.x
[2] Y SHIBOUTA. Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2’-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2’-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).[J]. Journal of Pharmacology and Experimental Therapeutics, 1993, 266 1: 114-120.
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| Company Name: |
Musechem
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| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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