| Identification | Back Directory | [Name]
Cbz-N-amido-PEG2-acid | [CAS]
1347750-76-8 | [Synonyms]
CBZ-AEEP
CBZ-NH-PEG2-COOH
CBZ-NH-PEG2-acid
Cbz-NH-PEG2-C2-acid
CBZ-N-AMIDO-PEG2-COOH
Cbz-N-amido-PEG2-acid
CBZ-NH-PEG2-propionic acid
4,7,12-Trioxa-10-azatridecanoic acid, 11-oxo-13-phenyl- | [Molecular Formula]
C15H21NO6 | [MDL Number]
MFCD28142483 | [MOL File]
1347750-76-8.mol | [Molecular Weight]
311.33 |
| Hazard Information | Back Directory | [Description]
Cbz-N-amido-PEG2-acid is a PEG linker containing a CBZ-protected amino group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected by acidic conditions. | [Uses]
Cbz-NH-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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