| Hazard Information | Back Directory | [Description]
CM764 is a potent and selective antagonist of sigma-2 receptors, a novel derivative of SN79. | [Uses]
CM764 is an activator for sigma receptor with Ki of 86.6 and 3.5 nM for sigma-1 receptor and sigma-2 receptor. CM764 increases cytoplasmic calcium, NAD+/NADH, and ATP levels, and decreases the concentration of ROS[1]. | [IC 50]
Sigma 2 Receptor: 3.5 nM (Ki); Sigma 1 Receptor: 86.6 nM (Ki) | [References]
[1] Nicholson H, et al., Sigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43. DOI:10.1124/jpet.115.228387 |
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