| Identification | Back Directory | [Name]
ALATRIOPRILAT | [CAS]
135038-59-4 | [Synonyms]
Fasidotrilat
ALATRIOPRILAT
L-Alanine, N-[(2S)-3-(1,3-benzodioxol-5-yl)-2-(mercaptomethyl)-1-oxopropyl]- | [Molecular Formula]
C14H17NO5S | [MDL Number]
MFCD09837671 | [MOL File]
135038-59-4.mol | [Molecular Weight]
311.35 |
| Hazard Information | Back Directory | [Uses]
Alatrioprilat is an orally active inhibitor of angiotensin-converting enzyme (ACE) (IC50=19.6 nM; Ki=9.8 nM) and enkephailnase (IC50=6.1 nM; Ki=5.1 nM). Alatrioprilat plays a key role in the metabolism of hormonal peptides through the degradation of nitric oxide and atrial natriuretic factor (ANF). Alatrioprilat can be used in the study of cardiovascular diseases[1]. | [References]
[1] Gros C, et al. Mixed inhibitors of angiotensin-converting enzyme (EC 3.4. 15.1) and enkephalinase (EC 3.4. 24.11): rational design, properties, and potential cardiovascular applications of glycopril and alatriopril[J]. Proceedings of the National Academy of Sciences, 1991, 88(10): 4210-4214. DOI:10.1073/pnas.88.10.4210 |
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